Protein Modification Reagents
Advanced Biomatrix Extralink PEGDA Thiol-reactive crosslinker for HyStem-C and HyStem-HP, 5 units x 2.5 mL
Extralink PEGDA is a thiol-reactive crosslinker designed for use in HyStem-C and HyStem-HP kits. Pack comes with Buffer B. HyStem V2.0 kit components are reconstituted with a buffered 1X PBS. The resulting components will also result in a pH neutral isotonic salt hydrogel. The ending pH, osmo, and rheological properties are the same from Version 1.0 to Version 2.0. Extralink is polyethylene diacrylate (PEGDA) with a molecular weight of 3500 Da. It is a thiol-reactive crosslinker that covalently reacts with the thiol groups in Glycosil, Heprasil and Gelin-S to form viscoelastic hydrogels. Extralink vials are >80% acrylated and supplied as the crosslinking component in all HyStem hydrogel kits. Extralink vials are paired with HyStem-C and HyStem–HP kits while Extralink-Lite vials are paired with HyStem hydrogel kits to provide comparable experiences despite the different HA concentrations.
Medchemexpress LLC Biotin-PEG2-aldehyde | 00-00-0 | 95.0% | 387.5 g/mol | C17H29N3O5S | 5 MG
Biotin-PEG2-aldehyde is a biotinylated PEG linker bearing a terminal aldehyde functional group for bioconjugation and PROTAC synthesis. The short PEG2 spacer increases aqueous solubility and provides a flexible linkage between the biotin tag and attached payloads.
- Terminal aldehyde enables chemoselective conjugation (hydrazone, oxime, reductive amination)
- PEG2 spacer improves aqueous solubility and flexibility
- Biotin tag enables affinity capture with streptavidin-based reagents
- Compatible with PROTAC and probe synthesis workflows
- High purity suitable for research use (95.0%)
- Available in small research-friendly pack sizes
Medchemexpress LLC DSPE-PEG-folate | 95.7% | 5000 (Average) | 10 MG
DSPE-PEG-Folate, MW 5000 is a pegylated phospholipid composed of distearoyl phosphatidylethanolamine (DSPE) conjugated to polyethylene glycol terminated with folic acid. It is used to impart folate-receptor targeting to liposomes, micelles, and other nanocarriers for targeted drug delivery and receptor-specific binding studies.
- Enables folate-receptor mediated targeting of nanocarriers.
- Average PEG molecular weight of 5000 provides an extended hydrophilic spacer.
- Integrates into lipid bilayers and forms stable micelles.
- High purity suitable for research applications.
- Available in small research pack sizes for formulation studies.
Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 | C69H115N11O17 | 1 MG
Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4-unit PEG antibody-drug conjugate (ADC) linker used to attach cytotoxic payloads such as MMAE to antibodies during ADC synthesis. It contains a Val-Cit dipeptide cleavable spacer and a para-aminobenzyl (PAB) self-immolative spacer with a PEG4 solubilizing linker, providing controlled payload release in target cells.
- Cleavable Val-Cit peptide spacer enabling enzyme-triggered release
- PAB self-immolative spacer for efficient payload release
- PEG4 linker improves solubility and spacer length
- High reported purity (approximately 99.9%)
- Soluble in DMSO and compatible with common in vivo formulations
Cayman Chemical VH 032 LInker 2 50mg
A VHL Ligand 1 derivative; comprises the VHL ligand domain and PEG linker of the BET inhibitor-containing PROTACs MZ2 and MZP-55
Medchemexpress LLC DSPE-N3 | 2839508-98-2 | 96.4% | 831.11 g/mol | C43H83N4O9P | 50 MG
DSPE-N3 is an azide-functionalized phospholipid used as a click-chemistry reagent for biochemical research. It enables covalent conjugation via azide-alkyne cycloaddition and is commonly used to functionalize liposomes, nanoparticles, and biomolecules for labeling or targeted delivery applications.
- Contains an azide functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free reactions.
- Suitable for liposome and surface functionalization in biochemical studies.
- Supplied as a white to off-white solid with high purity.
- Soluble in DMSO (12.5 mg/mL) with sonication and heating.
- Recommend sealed storage at 4°C; in solution: -80°C (6 months), -20°C (1 month).
Avanti Polar Lipids DMG-PEG 2000, 160743-62-4, powder, 1g
Molecular Formula C122H242O50 (average MW due to polydispersity of PEG), Purity >99%, Formula Weight 2509.200, Storage Temperature -20, 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000
![Medchemexpress LLC Poly(oxy-1,2-ethanediyl), α-[6-[[(3β)-cholest-5-en-3-yl]oxy]-1,6-dioxohexyl]-ω-[[6-[[(3β)-cho | 69068-97-9 | MFCD00151772 | 1055.60 g/mol | C68H110O8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000283629.png-250.jpg)
Medchemexpress LLC Poly(oxy-1,2-ethanediyl), α-[6-[[(3β)-cholest-5-en-3-yl]oxy]-1,6-dioxohexyl]-ω-[[6-[[(3β)-cho | 69068-97-9 | MFCD00151772 | 1055.60 g/mol | C68H110O8 | 100 MG
Cholesterol-PEG 600 is a cholesterol-polyethylene glycol conjugate used as an amphiphilic lipid modifier for liposome formulation and related life-science research. It enhances steric stabilization and aqueous compatibility of lipid assemblies, and is supplied as an off-white to light yellow oil with documented storage recommendations and batch-level quality documentation.
Cayman Chemical PEG 2000-C-DMG 1mg
A PEGylated derivative of DMG; has been used in combination with other lipids in the formation of LNPs for the delivery of siRNA; LNPs containing C-DMG-mPEG(2000) and encapsulating siRNA targeting the genes encoding PD-L1 and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells
eMolecules Mal-amido-PEG12-TFP ester | 1431295-77-0 | MFCD28505513 | 1g
Broadpharm | Mal-amido-PEG12-TFP ester | 1g | 550804214 | BP-22742 | 95.000 | 1431295-77-0 | MFCD28505513 | 916.911 | C40H60F4N2O17
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Tetrazine-SS-PEG4-biotin | 99.4% | 824.05 Da | C35H53N9O8S3 | 5 MG
Tetrazine-SS-PEG4-Biotin is a cleavable PEG-based bioconjugation reagent containing a tetrazine reactive group and a biotin affinity tag for labeling and affinity workflows. It is designed for inverse electron-demand Diels-Alder (iEDDA) click reactions and can be used as an ADC linker or for general bioconjugation in research applications.
- Cleavable disulfide linker with four PEG units for improved solubility and cleavability.
- Tetrazine moiety enables rapid iEDDA click chemistry with trans-cyclooctene partners.
- Biotin tag supports affinity capture and detection workflows.
- High purity suitable for bioconjugation (99.4%).
- Storage stable when protected from light and stored under inert atmosphere at low temperatures.
Medchemexpress LLC Mc-peg2-va-pab-exatecan | 2845165-13-9 | 99.6% | 994.03 | C51H56FN7O13 | 10 MG
MC-PEG2-VA-PAB-Exatecan is an exatecan-based drug-linker conjugate designed for antibody-drug conjugate (ADC) research. It links the camptothecin-derived cytotoxic payload exatecan to a cleavable PEG2-Val-Cit-PAB linker to permit targeted intracellular release of the payload during ADC development.
- Exatecan payload confers potent topoisomerase I inhibition.
- Cleavable Val-Cit-PAB linker enables enzyme-triggered release inside target cells.
- PEG2 spacer improves solubility and conjugation flexibility.
- High reported purity supports reproducible research results.
- Available in mg-scale quantities suitable for ADC synthesis workflows.
Medchemexpress LLC Dbco-(peg2-vc-pab-mmae)2 | 2259318-55-1 | 99.2% | 2835.50 g·mol⁻¹ | C149H224N22O32 | 10 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a click-chemistry compatible ADC linker dimer that carries monomethyl auristatin E (MMAE) payloads on a cleavable Val-Cit-PAB spacer and features a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used for bioconjugation and synthesis of antibody-drug conjugates, enabling controlled intracellular release of MMAE via protease cleavage.
- Enables strain-promoted alkyne-azide cycloaddition for copper-free bioconjugation.
- Includes a Val-Cit-PAB protease-cleavable linker for intracellular payload release.
- Delivers MMAE warheads for potent tubulin inhibition after release.
- Available as a powder with multiple package sizes for research-scale synthesis.
- High supplied purity supports reliable conjugation and analytical characterization.
Medchemexpress LLC Benzyl-PEG5-Ots 1g
Benzyl-PEG5-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs
Avanti Polar Lipids 18:0 PEG2000 PE Chloroform | 474922-77-5 | 200mg
18:0 PEG2000 PE Chloroform | Purity: 99% | 474922-77-5 | 200mg